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Registro completo
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Biblioteca (s) : |
INIA Las Brujas; INIA Tacuarembó. |
Fecha : |
21/02/2014 |
Actualizado : |
16/05/2017 |
Tipo de producción científica : |
Serie FPTA |
Autor : |
DOMÍNGUEZ, L.; LÓPEZ, A.; ANDINA, M.J.; URES, X.; SALDAÑA, J.; MUNGUÍA, B.; CESIO, V.; HEINZEN, H.; BREIJO, M.; PALMA, S.; CASTRO, S. |
Afiliación : |
LAURA DOMÍNGUEZ, Universidad de la República (UdelaR)/ Facultad de Química; A. LÓPEZ, Universidad de la República (UdelaR)/ Facultad de Química; M. J. ANDINA, Universidad de la República (UdelaR)/ Facultad de Química; X. URES, Universidad de la República (UdelaR)/ Facultad de Química; J. SALDAÑA, Universidad de la República (UdelaR)/ Facultad de Química; B. MUNGUÍA, Universidad de la República (UdelaR)/ Facultad de Química; V. CESIO, Universidad de la República (UdelaR)/ Facultad de Química; H. HEINZEN, Universidad de la República (UdelaR)/ Facultad de Química; M. BREIJO, Universidad de la República (UdelaR)/ Facultad de Medicina; S. PALMA, UNC (Universidad Nacional de Córdoba) / Facultad de Ciencias Químicas; S. CASTRO, UNC (Universidad Nacional de Córdoba) / Facultad de Ciencias Químicas. |
Título : |
Fitoveterinarios antiparasitarios para especies productivas |
Fecha de publicación : |
2013 |
Fuente / Imprenta : |
Montevideo (UY): INIA, 2013. |
Páginas : |
Versión electrónica |
Serie : |
(Serie FPTA-INIA; 42) |
ISSN : |
1688-924X |
Idioma : |
Español |
Notas : |
Proyecto FPTA 259: Fitoveterinarios antiparasitarios para especies productivas. Período de Ejecución: Abril 2009 - Julio 2012 |
Contenido : |
Las parasitosis provocadas por endo y extoparásitos en especies productivas generan enormes pérdidas económicas. En un esfuerzo interdisciplinario, enmarcado en el proyecto recientemente finalizado, se planteó la búsqueda y desarrollo de un fitoveterinario antiparasitario. De las más de 40 muestras ensayadas de origen natural (extractos, infusiones, etc.), se pudieron seleccionar algunas por su relevante actividad como insecticida contra Haematobia irritans. Con ellas se prepararon formulaciones innovadoras (microcápsulas). Los resultados obtenidos fueron muy promisorios, y justifican continuar con etapas del desarrollo que implican realizar pruebas preliminares de eficacia para seleccionar la mejor formulación para escalar su preparación, y llevar a cabo las pruebas definitivas de eficacia en bovinos con infección de H. irritans, a efectos de desarrollar un novedoso fitoveterinario antiparasitario. |
Thesagro : |
ANTIPARASITARIO; ESPECIES PRODUCTIVAS; FITOVETERINARIO; H. IRRITANS; NEMATODO; RESISTENCIA. |
Asunto categoría : |
-- |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/2834/1/18429050213133348.pdf
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Marc : |
LEADER 01913nam a2200349 a 4500 001 1003556 005 2017-05-16 008 2013 bl uuuu u00u1 u #d 022 $a1688-924X 100 1 $aDOMÍNGUEZ, L. 245 $aFitoveterinarios antiparasitarios para especies productivas 260 $aMontevideo (UY): INIA$c2013 300 $aVersión electrónica 490 $a(Serie FPTA-INIA; 42) 500 $aProyecto FPTA 259: Fitoveterinarios antiparasitarios para especies productivas. Período de Ejecución: Abril 2009 - Julio 2012 520 $aLas parasitosis provocadas por endo y extoparásitos en especies productivas generan enormes pérdidas económicas. En un esfuerzo interdisciplinario, enmarcado en el proyecto recientemente finalizado, se planteó la búsqueda y desarrollo de un fitoveterinario antiparasitario. De las más de 40 muestras ensayadas de origen natural (extractos, infusiones, etc.), se pudieron seleccionar algunas por su relevante actividad como insecticida contra Haematobia irritans. Con ellas se prepararon formulaciones innovadoras (microcápsulas). Los resultados obtenidos fueron muy promisorios, y justifican continuar con etapas del desarrollo que implican realizar pruebas preliminares de eficacia para seleccionar la mejor formulación para escalar su preparación, y llevar a cabo las pruebas definitivas de eficacia en bovinos con infección de H. irritans, a efectos de desarrollar un novedoso fitoveterinario antiparasitario. 650 $aANTIPARASITARIO 650 $aESPECIES PRODUCTIVAS 650 $aFITOVETERINARIO 650 $aH. IRRITANS 650 $aNEMATODO 650 $aRESISTENCIA 700 1 $aLÓPEZ, A. 700 1 $aANDINA, M.J. 700 1 $aURES, X. 700 1 $aSALDAÑA, J. 700 1 $aMUNGUÍA, B. 700 1 $aCESIO, V. 700 1 $aHEINZEN, H. 700 1 $aBREIJO, M. 700 1 $aPALMA, S. 700 1 $aCASTRO, S.
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
30/06/2023 |
Actualizado : |
30/06/2023 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Circulación / Nivel : |
Internacional - -- |
Autor : |
GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. |
Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JORGE P. GARCÍA, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; VICKI ADAMS, Monash University, Parkville, Victoria, Australia; JOAQUÍN I. ARMENDANO, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; JULIANN BEINGESSER, California Animal Health and Food Safety Laboratoy, University of California at Davis, San Bernardino, CA; JULIAN I. ROOD, Monash University, Parkville, Victoria, Australia; FRANCISCO A. UZAL, Monash University, Parkville, Victoria, Australia. |
Título : |
Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. |
Complemento del título : |
Infectious Disease - Original Article. |
Fecha de publicación : |
2023 |
Fuente / Imprenta : |
Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 |
ISSN : |
0300-9858 (print); 1544-2217 (online). |
DOI : |
10.1177/03009858231171669 |
Idioma : |
Inglés |
Notas : |
Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- |
Contenido : |
ABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 MenosABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 ... Presentar Todo |
Palabras claves : |
Clostridium perfringens type D; Enterotoxemia; ETX; Experimental infection; Kidneys; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Renal pathology; Sheep. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
Marc : |
LEADER 03352naa a2200325 a 4500 001 1064216 005 2023-06-30 008 2023 bl uuuu u00u1 u #d 022 $a0300-9858 (print); 1544-2217 (online). 024 7 $a10.1177/03009858231171669$2DOI 100 1 $aGIANNITTI, F. 245 $aExperimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions.$h[electronic resource] 260 $c2023 500 $aArticle history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- 520 $aABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 653 $aClostridium perfringens type D 653 $aEnterotoxemia 653 $aETX 653 $aExperimental infection 653 $aKidneys 653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA 653 $aRenal pathology 653 $aSheep 700 1 $aGARCÍA, J. P. 700 1 $aADAMS, V. 700 1 $aARMENDANO, J. 700 1 $aBEINGESSER, J. 700 1 $aROOD, J. 700 1 $aUZAL, F. A. 773 $tVeterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669
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